Signal regulatory protein alpha (SIRPα)/CD47 interaction and function
نویسندگان
چکیده
منابع مشابه
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Stephen B. Willingham, Jens-Peter Volkmer, Andrew J. Gentles, Debashis Sahoo, Piero Dalerba, Siddhartha S. Mitra, Jian Wang, Humberto Contreras-Trujillo, Robin Martin, Justin D. Cohen, Patricia Lovelace, Ferenc A. Scheeren, Mark P. Chao, Kipp Weiskopf, Chad Tang, Anne Kathrin Volkmer, Tejaswitha J. Naik, Theresa A. Storm, Adriane R. Mosley, Badreddin Edris, Seraina M. Schmid, Chris K. Sun, Mei-...
متن کاملThe Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response
Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...
متن کاملRegulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα...
متن کاملReplication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors "(Willingham et al., 2012). Here we report the results of those experiments. We fou...
متن کاملthe expression of signal regulatory protein-alpha in normal and osteoarthritic human articular cartilage and its involvement in chondrocyte mechano-transduction response
signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2009
ISSN: 0952-7915
DOI: 10.1016/j.coi.2009.01.008